sleep disorders
Conditions
Interventions
Esketamine Group:Intravenous injection of 0.2 mg/kg esketamine during operation
Normal Saline Placebo Group:Intravenous saline during surgery
Sponsors
Zhejiang Xiaoshan Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Preoperative sleep disorder is defined as a Pittsburgh Sleep Quality Index (PSQI) total score > 5. 2. Age 18-65 years, female. 3. American Society of Anesthesiologists (ASA) classification I-II. 4. Planned elective hysteroscopic surgery under intravenous general anesthesia (such as endometrial polyp removal, intrauterine adhesion separation, submucosal fibroid removal, etc.). 5. Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Contraindications or allergies to esketamine, ketamine, general anesthetics, opioids, or non-steroidal drugs; 2. History of mental illness, cognitive impairment, or inability to cooperate with questionnaire completion; 3. Severe cardio-cerebrovascular diseases (uncontrolled hypertension, unstable angina pectoris, severe arrhythmia), hepatic and renal insufficiency (Child-Pugh class C, CrCl 3 months) regular use of sedative-hypnotics, antidepressants, or opioids preoperatively; 6. Pregnant or lactating women; 7. Expected operative time exceeding 1 hour, or major unexpected intraoperative changes such as conversion to laparotomy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sleep disturbance after hysteroscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| sleep quality;pain intensity;consumption of analgesics; | — |
Countries
China
Contacts
Public ContactHua Xing
Zhejiang Xiaoshan Hospital
Outcome results
None listed