Moderate to Severe Visual Impairment
Conditions
Interventions
Visual Impairment Group:None
Control Group:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
25 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion Criteria for Subjects in the Visual Impairment Group (1)Aged between 25 and 60 years old; (2)Best-corrected visual acuity (BCVA) of the better-seeing eye = 20/20 (1.0); (3)Willing to participate in this experiment and cooperate with experimental procedures; (4)Able to understand experimental tasks and accurately express personal perceptions.
Exclusion criteria
Exclusion criteria: 1. Exclusion Criteria for Subjects with Visual Impairment (1) Suffering from peripheral nervous system diseases, central nervous system diseases, cardiac diseases, psychiatric disorders, diabetes, or hyperthyroidism; (2) Previous receipt of chemotherapy or radiotherapy; (3) Presence of implanted metallic or electronic devices in the body, or a history of implantation surgery with undetermined material composition; (4) Severe claustrophobia or other contraindications to magnetic resonance imaging (MRI); (5) Cognitive impairment, sensory dysfunction, or motor dysfunction; (6) Cortical blindness; (7) Trauma to the dorsal hand tissue, fingers, or innervating nerves at the junction of the index finger and thumb; (8) Rough, scaly, or scarred skin at the experimental testing site; (9) Impaired communication ability and inability to accurately describe subjective sensations; (10) Refusal to cooperate, poor compliance, or judged by investigators to be unsuitable for continued participation in this experiment; (11) Voluntary request to withdraw from the experiment. 2. Exclusion Criteria for Control Group Subjects (1) Suffering from peripheral nervous system diseases, central nervous system diseases, cardiac diseases, psychiatric disorders, diabetes, or hyperthyroidism; (2) Previous receipt of chemotherapy or radiotherapy; (3) Presence of implanted metallic or electronic devices in the body, or a history of implantation surgery with undetermined material composition; (4) Severe claustrophobia or other contraindications to magnetic resonance imaging (MRI); (5) Cognitive impairment, sensory dysfunction, or motor dysfunction; (6) Past or current visual acuity loss caused by ocular diseases at the time of testing; (7) History of any ocular surgery; (8) Trauma to the dorsal hand tissue, fingers, or innervating nerves at the junction of the index finger and thumb; (9) Rough, scaly, or scarred skin at the experimental testing site; (10) Impaired communication ability and inability to accurately describe subjective sensations; (11) Refusal to cooperate, poor compliance, or judged by investigators to be unsuitable for continued participation in this experiment; (12) Voluntary request to withdraw from the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mechanical Perception Threshold;Two-point Discrimination;Temperature Difference Discrimination Ability;Head fMRI images; | — |
Countries
China
Contacts
Public ContactLongqian Liu
West China Hospital, Sichuan University
Outcome results
None listed