Parkinson’s disease
Conditions
Interventions
Gold Standard:The foremost diagnostic criterion is to establish definite parkinsonism, defined as the presence of bradykinesia plus at least one of the other two cardinal features—rest tremor or rigid
>= 2 supportive criteria
no red flags.
Probable PD: no absolute exclusions
red flags must be offset by supportive criteria – 1 red flag needs >=1 support
2 flags need >=2 support
>2 flags exclude diagnosis.
Index test:Plasma neuron-derived exosomes were isolated and their a-synuclein content was quantified by magnetic-particle chemiluminescence immunoassay.
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 45 to 80 years, regardless of gender. 2.Diagnosed with Parkinson’s disease (PD) according to the 2015 Movement Disorder Society (MDS) diagnostic criteria. 3.Ability to understand the study procedures, willingness to participate, and provision of a signed informed consent form. 4.Age- and sex-matched healthy subjects.
Exclusion criteria
Exclusion criteria: 1.Patients with other neurological diseases such as cerebrovascular disease, hydrocephalus, brain tumors, or traumatic brain injury. 2.Patients with severe heart disease, organic damage to the liver, kidneys, or other organs, or severe hepatic or renal insufficiency. 3.Patients with severe cognitive impairment, major psychiatric disorders (e.g., schizophrenia), or severe psychological disorders that prevent cooperation with the examinations. 4.Any other circumstances that, in the investigator's judgment, make the patient unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity;Area Under the Curve;Specificity;Youden’s index; | — |
Countries
China
Contacts
Public ContactSu Wen
Beijing Hospital
Outcome results
None listed