Knee osteoarthritis
Conditions
Interventions
KOA Patient Group:None
Healthy Control Group:None
Sponsors
Hefei First People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 50 to 70 years old; 2. KOA group: Patients diagnosed with Kellgren-Lawrence grade ?–? knee osteoarthritis, scheduled for arthroscopic surgery, with synovial hyperplasia and cartilage wear visible under arthroscopy; 3. Control group: Patients with isolated knee trauma requiring arthroscopic exploration, without imaging manifestations of cartilage degeneration or history of chronic joint pain; 4. Complete clinical data, voluntary participation in this study and signed informed consent for human specimen research;
Exclusion criteria
Exclusion criteria: 1. Patients complicated with rheumatoid arthritis,; 2. Gouty arthritis and other inflammatory joint diseases; those with continuous use of glucocorticoids or lipid-lowering drugs within the past 3 months; 3. Patients with severe hepatic and renal dysfunction or a history of systemic malignant tumors; 4. Subjects with missing clinical data that cannot complete testing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative protein expression level of ACOX1;Relative protein expression level of ACOX1; | — |
Countries
China
Contacts
Public ContactGuosong Han
Hefei First People's Hospital
Outcome results
None listed