Safety and Efficacy of Carbon Dioxide Pre-inflation for Lung Collapse During One-lung Ventilation in Video-Assisted Thoracoscopic Surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600127685

Enrollment

Unknown

Registered

2026-07-06

Start date

2026-07-07

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pulmonary nodule

Interventions

B group (Control group) :Lung collapse on the operative side was achieved using the conventional method (inhalation of pure oxygen)

A group (trial group):Induction of atelectasis in the operative-side lung through carbon dioxide pre-inflation

Phase I: Single-Arm Study:Induction of atelectasis in the operative-side lung through carbon dioxide pre-inflation

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-65years old; 2. ASA score grade II.-III. 3. Scheduled for elective thoracoscopic thoracic surgery and planned to undergo one-lung ventilation using a left-sided double-lumen endotracheal tube; 4. The patient or their legal representative has been fully informed and has signed a written informed consent form.

Exclusion criteria

Exclusion criteria: 1. Severe chronic obstructive pulmonary disease, severe restrictive ventilatory dysfunction, or preoperative pulmonary function tests indicating an FEV1/FVC ratio of less than 50%, or the presence of resting hypercapnia. 2. Preoperative hypoxemia at rest; 3. Moderate-to-severe pulmonary arterial hypertension, or moderate-to-severe right heart failure. 4. Unstable coronary artery disease, recent myocardial infarction, uncontrolled severe arrhythmia, or severe heart failure. 5. Increased intracranial pressure, or the presence of a neurological disorder that may be exacerbated by CO2 retention; 6. Patients deemed unlikely to tolerate one-lung ventilation based on preoperative assessment, including those with severe hypoxic reserve, severe pulmonary infection, severe diffusion impairment, or those in whom oxygenation is expected to be difficult to maintain during one-lung ventilation. 7. BMI >35 kg/m²; 8. Pregnant or breastfeeding women; 9. Patients with severe liver or kidney failure, active infections, or other conditions that may significantly increase perioperative risk; 10. Other circumstances deemed by the researchers to make a participant unsuitable for this study.

Design outcomes

Primary

Measure	Time frame
Success rate of Carbon Dioxide Pre-inflation for Lung Collapse;Time required to achieve satisfactory lung collapse;	—

Secondary

Measure	Time frame
Arterial carbon dioxide partial pressure(PaCO2);Appearance time of identifying the intersegmental plane;Lung atelectasis score;Pulse oxygen saturation(SpO2);Arterial Blood pH;End-tidal carbon dioxide partial pressure;	—

Countries

China

Contacts

Public ContactWang Jiebo

Fujian Medical University Union Hospital

258960368@qq.com+86 15959004325

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026