Cognitive problems from small vessel brain disease1.Age over 40 years2.Neurologist conducts a neurological examination, with no signs of focal neurological deficits 3.To make this study as natural and realistic as possible, participants may have cardiovascular risk factors such as hypertension, hyperlipidemia, and diabetes4.Montreal Cognitive Assessment : A scale used for the rapid screening of co
Conditions
Interventions
No intervention group:None
Sponsors
Shanghai TCM-Integrated Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 93 Years
Inclusion criteria
Inclusion criteria: 1.Age over 40 years; 2.Neurologist conducts a neurological examination, with no signs of focal neurological deficits; 3.To make this study as natural and realistic as possible, participants may have cardiovascular risk factors such as hypertension, hyperlipidemia, and diabetes; 4.Montreal Cognitive Assessment : A scale used for the rapid screening of cognitive impairment. It includes 11 test items covering eight cognitive domains: attention and concentration, executive function, memory, language, visuospatial skills, abstract thinking, calculation, and orientation. The total score is 30 points, with>=26 considered normal; scores below 26 are eligible for inclusion;
Exclusion criteria
Exclusion criteria: 1.History of stroke or other neurological diseases; 2.Severe heart, liver, kidney, lung, or tumor diseases; 3.Presence of autoimmune diseases; 4.Infection at the time of enrollment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lacunar infarction;Perivascular Spaces;leukodystrophy;Cerebral microbleeds;Montreal Cognitive Assessment scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Thyroid-stimulating hormone;Glycated Hemoglobin;low-density lipoprotein cholesterol;uric acid;Superoxide dismutase; | — |
Countries
China
Contacts
Public ContactXiaoying Liu
Shanghai TCM-Integrated Hospital
Outcome results
None listed