Stroke
Conditions
Interventions
Individualized Precision Group:Based on fNIRS and machine learning, an individualized target model for PSCI was constructed to output individualized target coordinates for each patient. Precise naviga
Traditional empirical group:Stimulation site: left dorsolateral prefrontal cortex (DLPFC). rTMS was applied at 10 Hz, 100% RMT, with 2000 pulses per session, for 4 consecutive weeks.
Sham stimulation group:Based on fNIRS and machine learning, an individualized target model for PSCI was constructed to output individualized target coordinates for each patient. Precise navigation and
Sponsors
Hubei Provincial Government Directly-Affiliated Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for cerebral infarction, confirmed by head CT or MRI examination; 2. Aged 30–85 years; 3. First onset, disease course 1–6 months; 4. No cognitive impairment before onset, with MoCA score 11–26 after stroke; 5. No severe aphasia, able to cooperate with various functional assessments, stable vital signs, and no progressive neurological symptoms; 6. The patient or their family members are fully informed and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with skull defects who are ineligible for the relevant treatment; 2. Patients with a history of psychiatric disorders or other major neurodegenerative dementia diseases; 3. Patients with severe cardiac, hepatic, renal or other organ damage, severe aphasia, visual or auditory impairment, who are unable to cooperate with treatment and relevant assessments; 4. Patients with cognitive impairment caused by other factors such as drugs or intoxication; 5. Patients with a history of epilepsy or contraindications to rTMS; 6. Patients currently participating in other clinical trials that may affect the outcomes of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive Function;Quantifying/measuring executive function;Hemodynamic measures during resting state and a 1?back working memory task; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events; | — |
Countries
China
Contacts
Public ContactXia Wenguang
Hubei Provincial Government Directly-Affiliated Hospital
Outcome results
None listed