Contact lens-associated dry eye syndrome (CLDE)
Conditions
Interventions
control group:Use 0.1% sodium hyaluronate eye drops, 2 weeks.
experimental group:Use Cationorm eye drops, 2 weeks
Sponsors
Tianjin Medical University Eye Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Adult volunteers aged 18~40 years with refractive errors (-0.50D ~ -6.00D) and no other eye diseases; 2.Able to understand and voluntarily sign written informed consent forms, and cooperate throughout the entire research process; 3.Voluntarily wear contact lenses for 2 weeks; 4.Voluntary use of Cationorm eye drops or 0.1% sodium hyaluronate eye drops for 2 weeks; 5.No subjective symptoms related to dry eye, baseline OSDI score <10, NITBUT normal, corneal and conjunctival staining score of 0.
Exclusion criteria
Exclusion criteria: 1. Presence of active eye infections (such as conjunctivitis, keratitis, blepharitis, etc.); 2. Have undergone any eye surgery within the last 3 months prior to enrollment; 3. Have a history of contact lens allergy or are allergic to the components of the eye drops used in this study; 4. Systemic immunosuppressive therapy initiated within 3 months prior to enrollment; 5. Patients with systemic diseases affecting the ocular surface (such as Sjögren's syndrome, diabetes, rheumatoid arthritis, etc.) or those using medications that may affect the ocular surface; 6. Women who are pregnant, breastfeeding, or planning to become pregnant during the study; 7. Having mental illness or cognitive impairment, unable to cooperate with research procedures; 8. The investigator determines that there are other circumstances unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| tear MMP-9 concentration (pg/mL);tear LTA concentration (pg/mL);Corneal and conjunctival staining (CS) score; | — |
Countries
China
Contacts
Public ContactRen Xinjun
Tianjin Medical University Eye Hospital
Outcome results
None listed