Acute appendicitis
Conditions
Interventions
Experimental group:Fasting, fluid replacement, conventional antibiotics and other treatments, as well as routine blood tests were administered. At the same time, intestinal preparation was carried out
Control group:The patient was immediately fasted and given fluid replacement. At the same time, routine blood tests were conducted. Each center provided a routine standard antibiotic treatment plan in
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older; 2. Uncomplicated acute appendicitis (UAA) suspected based on clinical presentation and definitively diagnosed by radiological imaging (ultrasound (US)/computed tomography (CT)/magnetic resonance imaging (MRI)), with the absence of appendicolith. UAA is defined by the typical symptoms, signs, and imaging findings of acute appendicitis without evidence of perforation, gangrene, abscess/phlegmon, or generalized peritonitis; 3. Written informed consent signed by patients or their family members.
Exclusion criteria
Exclusion criteria: 1. Imaging findings suggestive of appendiceal mucocele or suspected appendiceal neoplasm, or other possible acute abdominal conditions; 2. Immunodeficiency (e.g., absolute neutrophil count < 500/mm^3, chronic use of immunosuppressive drugs, active chemotherapy, or AIDS); 3. Women who are pregnant or lactating; 4. Allergic to or having contraindications to the drugs to be used in the study (antibiotics, laxatives); 5. Had received two or more doses of intravenous antibiotics before enrollment; 6. Intestinal tuberculosis, or inflammatory bowel disease that requires active treatment, or severe intestinal adhesions; 7. Severe organ dysfunction or abnormal coagulation function, unable to safely tolerate colonoscopy or with contraindications; 8. Malignant tumors that require active treatment; 9. Any disease that requires immediate hospitalization or emergency intervention; 10. Combined with other infectious diseases that require active antibiotic treatment; 11. Expected inability to cooperate in completing the research or follow-up; 12. Recurrent appendicitis; 13. Currently participating in other studies that may affect the results of this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with treatment success (initial treatment success and the absence of recurrence) at 1 year; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients with at least one complication within 1 year;Number and duration of hospital admissions per person within 1 year;Days absent from work or school due to illness per person within 1 year;Number of clinic visits or emergency room visits per person within 1 year;Shift in the distribution of Visual Analogue Scale (VAS) pain score at 48 hours;EQ-5D-5L at 1 year;Decision Regret Scale at 1 year; | — |
Countries
China
Contacts
Public ContactYang Xin
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed