Mild Cognitive Impairment
Conditions
Interventions
Combined Intervention:Active repetitive transcranial magnetic stimulation (rTMS) combined with square dance movement intervention. The rTMS is administered 5 times per week for the first 4 weeks, and
the square dance intervention is c
rTMS Intervention only:Active rTMS (intervention frequency is the same as Group 1) combined with a time-matched non-aerobic social activity control (3 times per week, 60 minutes per session).
Dance Movement Intervention (DMI) only:Sham rTMS stimulation (using a placebo coil that produces equivalent sound and somatosensory sensations but no actual magnetic field) combined with square dance
Control group:Sham rTMS stimulation combined with a time-matched non-aerobic social activity control.
Sponsors
Handan Central Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of amnestic or multi-domain MCI by a specialist physician according to the National Institute on Aging-Alzheimer's Association (NIA-AA) criteria. 2. Age between 50 and 85 years. 3. Montreal Cognitive Assessment (MoCA) score between 18 and 25. 4. Geriatric Depression Scale (GDS-15) score = 41). 6. Stable doses of any prescribed medications for at least 30 days prior to screening. 7. Sufficient visual and auditory acuity (with correction if necessary) to complete assessments and interventions. 8. Voluntarily agrees to participate and provides informed consent.
Exclusion criteria
Exclusion criteria: 1. Diagnosis of dementia (any type). 2. Presence of major psychiatric conditions (e.g., major depressive disorder, schizophrenia) or neurological disorders (e.g., Parkinson’s disease, stroke) that could confound cognitive assessment. 3. Contraindications to rTMS (e.g., history of seizures, metallic implants in the head). 4. Regular participation in structured exercise (>= 3 times per week) or another cognitive intervention program within the past six months. 5. Abuse of drugs or alcohol that could cause cognitive impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Montreal Cognitive Assessment (MoCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Memory: Assessed using the Wechsler Memory Scale, Fourth Edition (WMS-IV);Executive Function: Evaluated via the Trail Making Test (Parts A and B);Physical Performance: Measured using the 6-Minute Walk Test (6MWT) for functional exercise capacity and the Berg Balance Scale (BBS) for static and dynamic balance. ;Quality of Life: Assessed using the 12-item Short Form Health Survey (SF-12); | — |
Countries
China
Contacts
Public ContactQing He
Handan Central Hospital
Outcome results
None listed