Postoperative Nausea and Vomiting
Conditions
Interventions
Trial group:Intravenous fentanyl 0.5µg/kg during anesthesia induction, no additional fentanyl during anesthesia maintenance
Control group:Intravenous fentanyl 0.2µg/kg during anesthesia induction, additional fentanyl 0.1µg/kg before skin incision, at the beginning of wound suture, and during anesthesia maintenance accordin
Sponsors
The First Affiliated Hospital,Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged between 18 and 65 years; 2. Scheduled for elective thyroid surgery at the First Affiliated Hospital of Sun Yat-sen University; 3. Provided written informed consent by patient or legal guardian.
Exclusion criteria
Exclusion criteria: 1. Expected operative time > 3 h; 2. Neurological or psychiatric disorders; 3. Vestibular dysfunction; 4. Gastrointestinal diseases; 5. Use of antiemetics or steroids within 72 h before surgery; 6. Severe cardiac or respiratory diseases; 7. Cognitive impairment unable to cooperate with follow-up; 8. Allergy to any study medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting within 24 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rescue antiemetic use;Pain score during recovery;Time to first episode of nausea or vomiting;Incidence of nausea and vomiting during recovery;Incidence of tracheal intubation response;Rescue analgesic use;Severity of nausea and vomiting within 24 hours postoperatively;Worst postoperative pain within 24 hours;Incidence of hypotension during anesthesia induction; | — |
Countries
China
Contacts
Public ContactHuang Wenqi
The First Affiliated Hospital,Sun Yat-sen University
Outcome results
None listed