Non-arteritic central retinal artery occlusion (NA-CRAO)
Conditions
Interventions
Neurology Thrombolytic Therapy Team:Intravascular thrombolysis
Routine ophthalmic treatment group:conventional treatment
Sponsors
The First Affiliated Hospital of USTC
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Definite diagnosis of non-arteritic central retinal artery occlusion by fundus findings and/or OCT; 2.Initial visual acuity = 0.1; 3.Age = 18 years; 4.Time from onset = 24 hours; 5.Signed informed consent from the patient and family;
Exclusion criteria
Exclusion criteria: 1.Fundus examination revealed no definite embolic site in the retinal artery, and macular OCT showed non-inner retinal edema. 2.Arteritic CRAO (central retinal artery occlusion) or giant cell arteritis; 3.Pre-existing blinding eye disease; after evaluation and treatment, visual function remains at the level of blindness; 4.Branch retinal artery occlusion, combined with central retinal artery and vein occlusion, proliferative diabetic retinopathy, ocular hypertension, and suspected ophthalmic artery occlusion. 5.CRAO related to facial cosmetic fillers; 6.MRI/CT revealed intracranial hemorrhage; 7.History of acute coronary syndrome, myocardial infarction, coronary revascularization, cerebrovascular accident, or transient ischemic attack within the last 6 months. 8.Subject has medical or psychiatric illness, or any condition that could compromise the subject's health or could interfere with, limit, or confound the protocol-defined assessments. 9.Presence of an active systemic infection. 10.Systemic issues including uncontrolled blood pressure and blood glucose that may compromise thrombolytic therapy. 11.Inability to attend or comply with follow-up visits; 12.Pregnant women (confirmed by HCG); 13.Current use of oral anticoagulants such as warfarin, or treatment with heparin within the past 48 hours. 14.History of surgery, biopsy, or significant trauma within the last 2 months. 15.Presence of severe hepatic and renal impairment, pancreatitis, or active peptic ulcer disease. 16. There is cognitive impairment, with a Mini-Mental State Examination (MMSE) score of less than 27.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best corrected visual acuity; | — |
Secondary
| Measure | Time frame |
|---|---|
| central macular thickness; | — |
Countries
China
Contacts
Public ContactYonghao Gu
The First Affiliated Hospital of USTC
Outcome results
None listed