bipolar disorder
Conditions
Interventions
Treatment Group:Oral quetiapine, starting at 50mg/day, titrated up based on tolerance and efficacy within 2 weeks, with a treatment dose range of 200-400mg/day, for a
Sponsors
Hebei Provincial Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 65 years, regardless of gender; 2. Patients meet the diagnostic criteria for a depressive episode of Bipolar I Disorder or Bipolar II Disorder according to DSM-5; 3. HAMD-17 score >= 18 and HCL-32 score < 14; 4. No history of clear respiratory, urinary, digestive tract, or other infections within 1 month prior to enrollment; 5. No medication treatment (such as antidepressants, antipsychotics, mood stabilizers, etc.) within 1 week prior to enrollment; 6. BMI < 30 kg/m^2; 7. Understand the content of this study, able to cooperate in completing all study procedures, and provide written informed consent from the participant or their guardian.
Exclusion criteria
Exclusion criteria: 1. Exclude those diagnosed with other comorbid psychiatric disorders. 2. Exclude those who have used antibiotics within the past 4 weeks. 3. Exclude those who have used probiotics, prebiotics, or synbiotics within the past 4 weeks. 4. Exclude those who have undergone major gastrointestinal surgery (excluding cholecystectomy and appendectomy) in the past 5 years, or any history of intestinal resection, or active gastrointestinal disorders, including inflammatory bowel disease, ulcerative colitis, Crohn's disease, or active infectious gastroenteritis, colitis, or gastritis. 5. Exclude those currently experiencing severe suicidal ideation or behavior. 6. Exclude pregnant or breastfeeding women, or those planning pregnancy. 7. Exclude patients with contraindications to the study medication. 8. Exclude vegetarians, strict carnivores, or individuals with severely unbalanced dietary habits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory Cytokine Levels;Hamilton Depression Rating Scale-17 Total Score;Relative Abundance of Butyrate-Producers; | — |
Countries
China
Contacts
Public ContactLiu Xinglong
Hebei Provincial Mental Health Center
Outcome results
None listed