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Esketamine as an Adjuvant to Levobupivacaine in Thoracic Paravertebral Block for Thoracoscopic Lung Cancer Surgery: A Retrospective Propensity Score-Matched Cohort Study

Esketamine as an Adjuvant to Levobupivacaine in Thoracic Paravertebral Block for Thoracoscopic Lung Cancer Surgery: A Retrospective Propensity Score-Matched Cohort Study - ESK-TPVB Cohort

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600127625
Enrollment
Unknown
Registered
2026-07-03
Start date
2025-01-01
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small cell lung cancer

Interventions

Patients undergoing thoracoscopic lung cancer surgery who previously received TPVB with levobupivacaine alone:None
Patients undergoing thoracoscopic lung cancer surgery who previously received TPVB with levobupivacaine plus esketamine:None

Sponsors

Yixing Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Underwent elective thoracoscopic radical resection of non-small cell lung cancer at Yixing Hospital of Traditional Chinese Medicine; 2. Aged 18-75 years; 3. ASA physical status I-III; 4. Received general anesthesia combined with ultrasound-guided thoracic paravertebral block; 5. Complete medical records, anesthesia records, postoperative analgesia records, and primary outcome data.

Exclusion criteria

Exclusion criteria: 1. Contraindication to regional anesthesia; 2. History of chronic opioid use or chronic pain syndrome; 3. Severe hepatic impairment or severe renal impairment (eGFR <30 mL/min/1.73 m²); 4. Psychiatric disorder affecting pain or neuropsychiatric assessment; 5. Conversion to open thoracotomy or reoperation within 48 hours after surgery; 6. Missing key study data or incomplete records.

Design outcomes

Primary

MeasureTime frame
Cumulative sufentanil consumption within 48 hours after surgery;Postoperative pain intensity;

Secondary

MeasureTime frame
Time to first ambulation;Duration of chest tube placement;Postoperative length of hospital stay;

Countries

China

Contacts

Public ContactJing Yibing

Yixing Hospital of Traditional Chinese Medicine

493317824@qq.com+86 158 6150 0613

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026