IgA nephropathy
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria for IgAN patients: 1. Kidney biopsy pathology report confirms IgA nephropathy; 2. Complete clinical data available, including gender, age, blood pressure, serum creatinine, 24-hour urine protein, etc. Inclusion criteria for healthy controls: 1. Normal hemoglobin, liver function, kidney function, electrolytes, urine test, and stool test; 2. No hypertension, diabetes, obesity, liver disease, digestive system disease, or tumors; 3. Negative for infectious diseases. Inclusion criteria for patients needing total nephrectomy due to kidney tumor: 1. Has a malignant kidney tumor requiring unilateral nephrectomy.
Exclusion criteria
Exclusion criteria: Exclusion criteria for IgAN patients: 1. Already started relevant medication or began hemodialysis/peritoneal dialysis; 2. Concurrent liver disease, digestive system disease, diabetes, tumors, etc.; 3. Positive for infectious diseases; 4. Presence of diseases like systemic lupus erythematosus, Henoch-Schönlein purpura nephritis, chronic liver disease, etc., that cause secondary IgA mesangial deposition. Exclusion criteria for patients needing total nephrectomy due to kidney tumor: 1. Concurrent chronic kidney disease; 2. Positive for infectious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The average optical density value of GLP-1R immunohistochemical staining of human kidney tissue sections;The levels of GLP-1 in the blood and urine supernatants; | — |
Countries
China
Contacts
Public ContactJunjun Zhang
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed