Neonatal non-IgE-mediated Cow's Milk Protein Allergy
Conditions
Interventions
Patients with CMPA:None
Control group:None
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1.Age at admission <= 28 days; 2.The patient clinically presents with digestive or cutaneous symptoms including hematochezia, vomiting, abdominal distension, diarrhea, constipation and eczema; 3. Patients who were admitted to our neonatal ward between January 1, 2019, and December 1, 2024.
Exclusion criteria
Exclusion criteria: 1.Those with a confirmed diagnosis of gastroesophageal reflux disease, neonatal necrotizing enterocolitis (NEC), or infectious enteritis; 2.Those with coagulation disorders, inherited metabolic diseases, or congenital digestive tract malformations; 3.Those with primary or secondary lactose intolerance; 4.Those diagnosed with IgE-mediated cow's milk protein allergy via clinical or laboratory tests, to ensure that the study cohort conforms to clinical trials focusing on neonatal cow's milk protein allergy predominantly mediated by non-IgE pathways.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| A total of 463 neonates were enrolled after PSM, including 117 cases in the CMPA group and 346 cases in the non-CMPA group. Multivariate Logistic regression analysis showed that maternal allergic hist; | — |
Countries
China
Contacts
Public ContactWei Liao
The First Affiliated Hospital of Army Medical University
Outcome results
None listed