Intestinal edema
Conditions
Interventions
TAP group (Transversus Abdominis Plane block group):Ultrasound-guided transversus abdominis plane block (TAP block): performed before anesthesia induction and surgical start, by trained anesthesiologi
Control group:Conventional anesthesia management (without TAP block): induction with dexmedetomidine, lidocaine, sufentanil, propofol, vecuronium
maintenance with sevoflurane, propofol, remifentanil, vecuronium
intraoperative management includes routine fluid administration (crystalloid-colloid ratio 2:1), prophylactic medications (palonosetron, dexamethasone, parecoxib sodium)
Sponsors
The First People’s Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective laparoscopic colorectal cancer surgery; 2. Age range: 18-80 years old; 3. Body Mass Index (BMI) 18-35kg/m^2; 4. American Society of Anesthesiologists (ASA) grades I-III; 5. Tolerant individuals to all relevant drugs in this study; 6. Those who voluntarily participate in this study and sign relevant informed consent forms.
Exclusion criteria
Exclusion criteria: 1. Cannot cooperate with nerve block patients; 2. Combining common diseases that cause intestinal edema (such as inflammatory bowel disease); 3. Patients with severe functional impairments in the heart, brain, kidneys, lungs, and liver, or other malignant tumor diseases; 4. Those who cannot understand the relevant rating scales.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ratio of dry to wet weight of intestinal tissue specimens; | — |
Secondary
| Measure | Time frame |
|---|---|
| Thickness of intestinal wall in tissue specimens;Abundance of tight junction proteins in intestinal tissue specimens;Intraoperative fluid input and output;Heart rate and mean arterial pressure (MAP);Serum levels of tumor necrosis factor-alpha (TNF-a);Postoperative gastrointestinal function I-FEED score;Time to first flatus, defecation, and initiation of clear liquid diet after surgery;Patient satisfaction level;Visual analog scale (VAS) score;Surgical duration and anesthesia duration;Intraoperative blood loss, blood transfusion volume, fluid infusion volume, and urine output;Consumption of intraoperative drugs such as propofol, sufentanil, and remifentanil;Postoperative opioid consumption;Visual analog scale (VAS) scores recorded on postoperative days 1, 3, and 7;Length of hospital stay;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactFeng Jiyin
The First People’s Hospital of Lianyungang
Outcome results
None listed