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Early efficacy prediction of adolescent depression: construction of a combined effect model of REM sleep and cortisol

Early efficacy prediction of adolescent depression: construction of a combined effect model of REM sleep and cortisol

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600127568
Enrollment
Unknown
Registered
2026-07-02
Start date
2026-07-02
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depressive disorder

Interventions

Adult Depression Group:None

Sponsors

Southern Medical University Southern Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. The age should be >=12 years old and 17 points, Yang's manic scale <4 points; 4. Take escithalan or sertraline as an antidepressant; 5. Participate voluntarily and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Combined with other mental disorders (bipolar disorder, schizophrenia, etc.); 2. Suffering from intellectual disability; 3. There is a history of substance abuse or dependence within 6 months before the assessment; 4. Combined with serious somatic diseases or organic diseases in the brain (traumatic brain injury, cerebral infarction, cerebral hemorrhage, etc.); 5. Other situations that are not suitable for this project (such as women who are pregnant, lactating or planned to become pregnant, etc.);

Design outcomes

Primary

MeasureTime frame
Change in Hamilton Depression Rating Scale 17-item (HAMD-17) score from baseline to week 4 after the start of intervention;Change in HAMD-17 score;Change in MEQ-5 score;

Secondary

MeasureTime frame
Change in PSQI score;The marked efficacy from baseline to the 2nd and 4th weeks after the intervention began (marked efficacy was defined as a decrease of > =50% in the total score of HAMD-17 at the end of the 2nd week co;Change in HAMA score;Changes in the score of the Baker Depression Table-II (BDI-II);

Countries

China

Contacts

Public ContactLuo Xian

Southern Medical University Southern Hospital

2443180803@qq.com+86 15521073773

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026