Pulmonary arterial hypertension (PAH)
Conditions
Interventions
Group with lung cancer and concomitant cardiopulmonary disease:None
Control group with isolated lung cancer:None
Sponsors
Huzhou Center Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Group with lung cancer and concomitant cardiopulmonary disease (100 cases): Paraffin-embedded tissue blocks from surgical resections of lung cancer archived in the Pathology Department, where the same patient was simultaneously diagnosed with cardiopulmonary diseases such as chronic obstructive pulmonary disease or heart failure. (2) Control group with isolated lung cancer (50 cases): Paraffin-embedded tissue blocks from surgical resections of lung cancer archived in the pathology department, where the same patient had no concomitant cardiopulmonary diseases such as chronic obstructive pulmonary disease or heart failure, nor a history of metabolic diseases such as diabetes.
Exclusion criteria
Exclusion criteria: 1. Samples meeting any of the following criteria shall not be included: (1) The sample donor is known to have an infectious disease such as hepatitis B, hepatitis C, human immunodeficiency virus (HIV) infection or syphilis. 2. The sample donor’s clinical diagnostic data is severely incomplete, or the paraffin tissue blocks exhibit serious quality issues such as severe loss of sections, damage, poor fixation or tissue autolysis, rendering them unsuitable for subsequent testing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression levels of NAT10, LDHA and HIF-1a in lung tumor tissues; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of media thickness in the patient’s small arteries ;cellular markers associated with media proliferation;levels of histone lactylation;haemodynamic parameters such as pulmonary artery; | — |
Countries
China
Contacts
Public ContactShan Huitong
Huzhou Center Hospital
Outcome results
None listed