Paclitaxel-induced peripheral neurotoxicity
Conditions
Interventions
90-minute group:The 90-minute group received 90 minutes of ice gloves and 90 minutes of foot compression pump on the basis of routine education and conventional fluid
30-minute group:The 30-minute group, based on standard education and routine fluid infusion, will receive 30 minutes of ice gloves plus 30 minutes of foot compression
60-minute group:The 60-minute group, based on standard education and routine fluid infusion, received 60-minute ice gloves plus a 60-minute foot compression pump (20
Sponsors
Shandong Provincial Qianfoshan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. All cases are confirmed as malignant tumors by pathology or cytology; 2. Planned to undergo 4-6 cycles of a taxane-based regimen; 3. All are suitable for chemotherapy with either a taxane-alone regimen or a taxane combined with monoclonal antibody drugs; 4. Karnofsky score above 60, normal heart, liver, and kidney function, with an expected survival of more than 6 months; 5. Age over 18 years; 6. Able to read text or answer questions correctly; 7.Sign the informed consent form and voluntarily participate in this study.
Exclusion criteria
Exclusion criteria: 1. Patients with diabetic neuropathy, cervical spondylosis, untreated spinal cord compression syndrome, spinal canal stenosis, or central nervous system tumors with spinal cord or nerve root compression before chemotherapy; 2. Patients with peripheral neuropathy caused by toxins, infections, or radiotherapy, as well as those receiving other treatments that may cause neurotoxicity; 3. Patients with a history of severe psychiatric or neurological disorders; 4. Those who are overly sensitive to cold sensations or have other skin conditions; 5.Patients who have used chemotherapy drugs for <=2 courses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in peripheral neurotoxicity scale (EORTC QLQ-CIPN20) scores of study participants at different times; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain Score (NRS Scale);Fall Risk Assessment (MORSE Scale);Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactRuan Zhen
Shandong Provincial Qianfoshan Hospital
Outcome results
None listed