Degenerative Spine Disease (DSD)
Conditions
Interventions
Observation group:None
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. patients aged 40 to 80 years, with no gender restriction; 2. patients with a definite diagnosis of symptomatic posterior ligamentous hypertrophy, cervical spondylosis, and spinal stenosis based on clinical symptoms, signs, and cervical MRI, and scheduled to undergo posterior decompression surgery; 3. confirmed by CT to have no continuous or extensive ossification.
Exclusion criteria
Exclusion criteria: 1.Patients with extensive and continuous ossification of the posterior longitudinal ligament 2. There is a history of spinal tumors, infections, trauma or previous surgeries on the same segment of the spine 3. Combined with severe systemic diseases (such as active tumors, coagulation disorders, immune system diseases);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differentially expressed gene/protein pathways;Expression levels of COL1A1, COL2A1, ACAN, and a-SMA; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of pathological classification of hypertrophic ligament tissue;The activation status of key signaling pathways (such as TGF-ß, BMP); | — |
Countries
China
Contacts
Public ContactYuan Feng
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed