Optic neuropathies
Conditions
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
8 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age between 8 and 75 years old (inclusive), any gender. 2. Stable monocular or quadrantic visual field defects caused by glaucoma (with IOP controlled by medication or surgery), ocular trauma, optic neuritis, ischemic optic neuropathy, Leber hereditary optic neuropathy, or other optic nerve or macula-related diseases, with HFA 30-2/24-2 test MD = 6 months (based on imaging reports or medical records). 3. At least two visual field test results, and through medical history review, confirmation that the condition has been stable with no acute episodes in the past 3 months. 4. The 'study eye' must have a best corrected visual acuity >= 0.1 (ETDRS chart). If both eyes qualify, the one with the worse mean deviation (MD) in the visual field is preferred. If MD values are the same or cannot be compared, the eye with better visual acuity is selected. If only one eye meets all inclusion criteria, that eye is the 'study eye'. 5. Have basic understanding and communication skills and be able to follow study instructions. Mini-Mental State Exam (MMSE) score >= 24. Able and willing to complete all study procedures. 6. Ready to undergo this training, voluntarily participate in the study, understand the study's purpose, process, potential risks and benefits, and have signed the written informed consent approved by the Biomedical Research Ethics Committee of the Affiliated Eye Hospital of Wenzhou Medical University.
Exclusion criteria
Exclusion criteria: 1. Merging with other unstable or progressive eye diseases that might significantly affect completing training tasks or interpreting evaluation results. This includes, but is not limited to: active eye inflammation (like uveitis), uncontrolled glaucoma, severe cataracts. 2. OCT exams suggesting progressive structural damage: OCT images from the past three months show clear, clinically significant progressive thinning or thickening of key retinal layers, or active lesions like macular edema. 3. Clearly having visual neglect, agnosia, apraxia, or severe mental illness, cognitive impairment, dementia (MMSE score <24), making it impossible to understand or cooperate with the study process according to the researcher’s judgment. 4. History of epilepsy, or sensitivity to flickering lights or fast-moving patterns, posing a risk of photosensitive seizures. 5. Participated in other formal, systematic visual rehabilitation training or related clinical trials in the past 6 months. 6. Any other situations that the researcher believes could put the subject at high risk or interfere with the smooth conduct of the study and interpretation of results (such as severe cardiovascular or cerebrovascular disease, life expectancy less than 1 year, alcohol or drug abuse, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean Deviation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraocular Pressure;Best-Corrected Visual Acuity;Color Fundus Photography;Visual Field Index;Pattern Standard Deviation;Optical Coherence Tomography;Contrast Sensitivity;Macular Integrity Assessment;score of National Eye Institute Visual Function Questionnaire - 25;Near Stereoacuity; | — |
Countries
China
Contacts
Public ContactJun Jiang
Eye Hospital, Wenzhou Medical University
Outcome results
None listed