Periprosthetic Joint Infection
Conditions
Interventions
Gold Standard:The internationally recognized diagnostic criteria for periprosthetic joint infection (PJI), namely the 2018 International Consensus Meeting (ICM) criteria and/or the 2021 European Bone
Index test:Lyfstone Calprotectin Lateral Flow Test
Sponsors
Chinese PLA General Hospital Fourth Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged >=18 years, of either sex; patients scheduled for hip or knee revision arthroplasty for any reason (including single-stage revision, one-stage or two-stage revision, and debridement, antibiotics, and implant retention [DAIR] procedures); availability of an adequate synovial fluid sample (>=1 mL) obtained preoperatively or intraoperatively for calprotectin testing and routine synovial fluid analysis; and provision of written informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: **Exclusion criteria:** Patients who have received systemic antibiotics within 2 weeks prior to surgery (excluding perioperative prophylactic antibiotics); patients with active inflammatory arthropathies involving the target joint (such as rheumatoid arthritis, gouty arthritis, or psoriatic arthritis); patients with traumatic joint infections; patients who refuse joint aspiration; patients in whom joint aspiration has failed, including those in whom no synovial fluid is obtained or only inadequate/invalid synovial fluid is collected (e.g., contaminated or insufficient volume for diagnostic analysis); patients who have undergone joint aspiration or surgical intervention on the target joint within the past 3 months (excluding diagnostic aspiration); and any other conditions deemed inappropriate for inclusion by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Synovial fluid calprotectin test results ;Diagnostic accuracy for periprosthetic joint infection (PJI); | — |
Countries
China
Contacts
Public ContactZhang Guoqiang
Chinese PLA General Hospital Fourth Medical Center
Outcome results
None listed