Alzheimer’s disease
Conditions
Interventions
RIC intervention group:Bilateral upper arm wearing standard medical intermittent pneumatic compression cuffs, pressure higher than systolic blood pressure by 30-50 mmHg, maintained for 5 minutes, foll
Sham intervention control group:Wearing identical intermittent pneumatic compression cuffs, performing the same inflation-deflation cycles, but cuff pressure lower than patient's diastolic blood press
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients from the neurology outpatient clinic or inpatient ward of our hospital, aged 40–80 years, male or female; 2. Clinically diagnosed with mild-to-moderate Alzheimer’s disease (AD) according to the 2024 diagnostic criteria for AD dementia established by the National Institute on Aging and the Alzheimer’s Association (NIA-AA); 3. Having a stable caregiver who can accompany the patient to the hospital for remote ischemic conditioning (RIC) intervention 5 days per week during the study period; 4. Able to cooperate with clinical assessments including MMSE, ADAS-cog, NPI, ADL, and other relevant scales; 5. Medication requirements: - Patients diagnosed with mild AD must have been on a stable dose of donepezil (2.5–5 mg/day) for at least 3 months before enrollment; - Patients diagnosed with moderate AD must have been on a stable combination of donepezil (2.5–5 mg/day) and memantine (5–10 mg/day) for at least 3 months before enrollment; 6. Willing to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of skin lesions, infection, lymphedema, severe pain, or severe peripheral arterial disease in the upper limbs that would preclude the use of a compression cuff; 2. Comorbid systemic diseases, such as a history of chronic kidney disease or creatinine clearance =160 mmHg or diastolic blood pressure >=100 mmHg), or a history of hypertensive crisis or hypertensive encephalopathy; 4. Presence of uncorrectable visual or hearing impairment that precludes completion of neuropsychological tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the cognitive subscale score of the Alzheimer's Disease Assessment Scale (ADAS-cog); | — |
Secondary
| Measure | Time frame |
|---|---|
| To record adverse events occurring throughout the study period, particularly those related to the RIC procedure (such as limb numbness, pain, ecchymosis, etc.), in order to evaluate the safety and tol;To compare the between-group differences in the changes of MMSE, NPI, and ADL scores at baseline and at each follow-up time point (weeks 4, 12, 24, 36, and 48) between the two groups.; | — |
Countries
China
Contacts
Public ContactZhao Beiyu
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed