None listed
Conditions
Interventions
Reproductive-age low-progesterone group:After intravenous injection of oxycodone at a dose of 0.1mg/kg, loss of consciousness was induced by target-controlled infusion of propofol.
Elderly postmenopausal group:After intravenous injection of oxycodone at a dose of 0.1mg/kg, loss of consciousness was induced by target-controlled infusion of propofol.
Middle-aged postmenopausal group:After intravenous injection of oxycodone at a dose of 0.1mg/kg, loss of consciousness was induced by target-controlled infusion of propofol.
Reproductive-age high-progesterone group:After intravenous injection of oxycodone at a dose of 0.1mg/kg, loss of consciousness was induced by target-controlled infusion of propofol.
Sponsors
Women’s Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Female patients aged 18–75 years. 2. American Society of Anesthesiologists (ASA) physical status class I–II. 3. Scheduled for elective minor gynecological surgery (e.g., hysteroscopy) under general anesthesia. 4. Voluntary participation in the study with signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of severe cardiac, hepatic, renal, or neurological diseases. 2. A history of hormone replacement therapy or use of endocrine-affecting drugs within the past 6 months. 3. A history of alcohol or drug abuse, or long-term use of sedatives, analgesics, or psychotropic medications. 4. Known allergy to propofol, oxycodone, or their excipients. 5. Body mass index (BMI) 35 kg/m². 6. Predicted difficult airway or high risk of reflux and aspiration. 7. Inability to cooperate or communicate during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Median effective concentration (EC??) of propofol for loss of consciousness (LOC) during anesthetic induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total consumption of propofol (mg);Propofol effect-site concentration (Ce, µg/mL) at LOC;Vital signs;Adverse events;Recovery time from drug cessation to spontaneous eye opening (min);Time to LOC (min); | — |
Countries
China
Contacts
Public ContactSun Lihong
Women’s Hospital, Zhejiang University School of Medicine
Outcome results
None listed