Postoperative pain after hemorrhoidectomy
Conditions
Interventions
Loratropine Sodium Group:Patients in the losofen sodium group received oral administration of losofen sodium tablets (60 mg every 8 hours as needed) for pain relief.
Amphetamine hydrocodone group:Patients in the amfeprofen oxycodone group received oral administration of amfeprofen oxycodone tablets (5mg / 6 hours as needed) for pain relief.
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. Patients diagnosed with severe circular mixed hemorrhoids according to the Chinese Guidelines for the Diagnosis and Treatment of Hemorrhoids (2020) and who underwent external dissection and internal ligation of mixed hemorrhoids during hospitalization; 3. Voluntarily sign the informed consent form and follow the requirements of the protocol;
Exclusion criteria
Exclusion criteria: 1.Patients with acute inflammatory reactions in the anal area (anal infection, abscess); 2. Patients with contraindications to non-steroidal anti-inflammatory drugs (such as gastric ulcers, asthma) and opioid contraindications (respiratory depression); 3. Patients who are allergic to non-steroidal anti-inflammatory drugs or paracetamol and oxycodone tablets; 4. Chronic inflammatory bowel disease (such as Crohn's disease); 5. There are severe diseases of vital organs or autoimmune insufficiency; 6. Pregnant women, lactating women or those who cannot use contraception during the study period; 7. Those with a history of severe systemic diseases or mental illness/neurological dysfunction; 8. Other circumstances where the researcher deems it inappropriate to participate in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The average VAS pain score of the subjects within 4 weeks after the operation;The average VAS pain score of the subjects within two weeks after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Actual dosage and frequency of the medication;The average VAS pain score 1 week after the operation;The HDSS score at the 4th week after the operation;The average VAS pain score 24 hours after the operation;The score of the European Five-Dimensional Health Quality of Life Scale (EQ-5D-3L) at the 4th week after the operation;Satisfaction level;The HDSS score at the 2nd week after the operation;The score of the European Five-Dimensional Health Quality of Life Scale (EQ-5D-3L) at the 12th week after the operation;The average VAS pain score 8 hours after the operation;The average VAS pain score 36 hours after the operation;The score of the European Five-Dimensional Health Quality of Life Scale (EQ-5D-3L) at the 2nd week after the operation;The HDSS score at the 12th week after the operation;Recurrent rate; | — |
Countries
China
Contacts
Public ContactMa Huangfu
China-Japan Friendship Hospital
Outcome results
None listed