Nasopharyngeal Skull Base Adenoid Cystic Carcinoma
Conditions
Interventions
Perineural Invasion Group:None
Non-Perineural Invasion Group:None
Sponsors
Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Before the initiation of any study-related activities, subjects and their parents/legal guardians shall sign a written informed consent in accordance with local requirements(Study-related activities refer to any procedures that would not be performed during the routine clinical management of the subjects). 2. Age between 18 and 65 years old (inclusive). 3. Pathologically confirmed nasopharyngeal skull base adenoid cystic carcinoma (NPSB-ACC), supported by: Imaging studies of the nasal cavity, paranasal sinuses, and skull base (high-resolution computed tomography [HRCT] + magnetic resonance imaging [MRI]); Nasal endoscopy.
Exclusion criteria
Exclusion criteria: 1. According to the researchers' judgment, the subjects and/or their parents/legal guardians are unable to understand and comply with the research requirements; 2. Currently participating in another clinical study or participating in any other clinical study within 30 days; 3. The participants and/or parents/legal guardians have a low expected level of compliance with the study procedures or are unable to understand the instructions/research documents for planning and conducting this study; 4. Any dependency between the sponsor or researchers due to formal or judicial practice; 5. Women of childbearing age who meet any of the following conditions: positive pregnancy test or pregnancy; 6. Diseases and health conditions:Severe acute or chronic diseases (such as COVID-19, chronic urticaria, mastocytosis, active pulmonary tuberculosis, type 1 diabetes, chronic renal failure), severe inflammatory diseases (liver, kidney), autoimmune diseases, immunodeficiency (including immunosuppression), immune complex-induced immune lesions (such as HIV, post-transplant patients, lupus, vitiligo, Graves' disease, multiple sclerosis);Severe mental and psychological disorders, including cooperation disorders (such as alcoholism or drug abuse);Recurrent episodes (such as febrile seizures, untreated epilepsy);Irreversible secondary changes in responsive organs (such as emphysema, bronchiectasis).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cell subset distribution characteristics in diseased tissues; | — |
Secondary
| Measure | Time frame |
|---|---|
| Exploratory Differential Gene Analysis; | — |
Countries
China
Contacts
Public ContactWeihong Jiang
Xiangya Hospital of Central South University
Outcome results
None listed