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Randomized Double-Blind Controlled Trial of Granulocyte-Macrophage Colony-Stimulating Factor on Endometrial Receptivity in Thin Endometrium

Randomized Double-Blind Controlled Trial of Granulocyte-Macrophage Colony-Stimulating Factor on Endometrial Receptivity in Thin Endometrium

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600127452
Enrollment
Unknown
Registered
2026-07-01
Start date
2026-07-01
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thin endometrium

Interventions

GM-CSF:GM-CSF infusion
Saline:Saline infusion

Sponsors

Chongqing Health Center for Women and Children
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
25 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. At least one of the IVF/ICSI-ET/FET procedures resulted in failure; 2. The thickness of the endometrium was less than 7 mm after a natural cycle or hormone replacement therapy; 3. The endometrium was repeatedly found to be thin and no abnormalities were detected during hysteroscopy within six months; 4. Both partners had normal chromosome tests. 5. At least one IVF/ICSI-ET/FET transfer has failed.

Exclusion criteria

Exclusion criteria: 1. Uterine anatomical abnormalities, like septate uterus, bicornuate uterus, or unicornuate uterus; 2. Organic lesions in the uterus or uterine cavity: endometrial polyps, intrauterine adhesions, submucosal fibroids, endometrial tuberculosis, etc.; 3. Contraindications for using GM-CSF: patients allergic to GM-CSF; 4. Long-term oral contraceptive users; 5. Clomiphene-stimulated cycles; 6. Hydrosalpinx; 7. Other internal medicine, surgical, or psychiatric conditions.

Design outcomes

Primary

MeasureTime frame
Endometrial thickness;

Countries

China

Contacts

Public ContactJuan Xie

Chongqing Health Center for Women and Children

1531375316@qq.com+86 23 63839850

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026