Cesarean section
Conditions
Interventions
Esketamine group:0.2 mg/kg of esketamine was administered by intravenous infusion for 10 minutes, followed by continuous infusion at a rate of 0.15 mg/kg per hour.
Dexmedetomidine group:0.6 µg/kg of dexmedetomidine was administered by intravenous infusion for 10 minutes, followed by continuous infusion at a rate of 0.6 µg/kg per hour.
control group:An equal amount of normal saline was infused intravenously for 10 minutes, followed by continuous infusion of the same amount of normal saline.
Sponsors
Yijishan Hospital of Wannan Medical College
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Pregnancy weeks: 37-42 weeks, age over 18 years old; 2. ASA score: I or II; 3. Clearly understand and voluntarily participate in this study, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have a history of allergy to esketamine or dexmedetomidine; 2. Have contraindications for intraspinal anesthesia; 3. Have a history of abuse of sedative and analgesic drugs or long-term use of psychotropic drugs; 4. Have severe cardiovascular or cerebrovascular diseases, severe gestational hypertension, preeclampsia or eclampsia; 5. Have a full stomach or increased intraocular pressure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Obstetric Quality of Recovery(ObsQoR-10); | — |
Secondary
| Measure | Time frame |
|---|---|
| mean pain score over 24 hours(NRS);Postoperative sleep quality score (Richards-Campbell);Postoperative anxiety and depression scores; | — |
Countries
China
Contacts
Public ContactWang Lipeng
Yijishan Hospital of Wannan Medical College
Outcome results
None listed