Postoperative delirium
Conditions
Interventions
Nitroglycerin group:Intravenous nitroglycerin
Nimodipine group:Intravenous infusion of nimodipine
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age = 60 years; 2. ASA classification of I to III; 3. Scheduled to undergo elective endoscopic nasal surgery under general anesthesia; 4. Agreement to participate in this study and complete the entire postoperative follow-up.
Exclusion criteria
Exclusion criteria: 1.MMSE score <17 (for uneducated individuals), <20 (for primary school education), <24 (for secondary education or above); 2.History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis; 3.Drug-related contraindications (severe sinus bradycardia, severe hypotension, uncontrolled hypertension, allergy, etc.); 4.Inability to communicate preoperatively (coma, severe dementia, or language barriers); 5.Severe liver dysfunction (Child-Pugh Class C); 6.Severe renal insufficiency (preoperative dialysis).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS Score; | — |
Countries
China
Contacts
Public ContactSu Liu
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed