Cataract
Conditions
Interventions
Diabetic cataract group:Preoperative cataract type, Postoperative reaction/response
Group of Complicated Cataract Secondary to Uveitis and Other Inflammatory Eye Diseases:None
high-myopia related cataract:None
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 40 and 80 years (inclusive), regardless of gender. 2. Clinically diagnosed as requiring phacoemulsification combined with intraocular lens implantation. Based on preoperative examinations, patients must be clearly classified into one of the following subgroups: Age-related cataract group: No other identifiable secondary causes. Diabetic cataract group: Documented history of type 2 diabetes mellitus. High myopia-associated complicated cataract group: Axial length >= 26.0 mm. Uveitis-associated or other inflammatory complicated cataract group: Documented history of uveitis or other ocular inflammatory diseases, with the condition currently stable. 3. Voluntary participation in the study with signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of acute ocular or systemic active infection (e.g., acute conjunctivitis, dacryocystitis, systemic infection, etc.). 2. History of severe intraocular diseases that may significantly affect aqueous humor or capsular composition (e.g., active uveitis, intraocular tumors, previous intraocular surgery, severe ocular trauma). 3. Known systemic metabolic or genetic diseases not falling within the subgroups of interest in this study (e.g., endocrine disorders other than diabetes, hereditary cataract syndromes, etc.), to avoid confounding factors. 4. Preoperative assessment reveals a corneal endothelial cell count significantly below the safe threshold, or other serious ocular conditions that increase surgical risk. 5. Pregnant or lactating women. 6. Any other condition deemed by the investigator as unsuitable for participation in this study (e.g., psychiatric disorders, inability to cooperate with follow-up, etc.);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RNA-seq, metabolomics, microbiomics;Risks Associated with Sample Collection (Risks of Anterior Chamber Puncture and Capsule Harvesting); | — |
Secondary
| Measure | Time frame |
|---|---|
| correlation analysis of clinical complications?biomarker discovery; | — |
Countries
China
Contacts
Public ContactTianyu Zheng
Shanghai Tenth People's Hospital
Outcome results
None listed