First-ever stroke, or previous lacunar infarction without residual sequelae
Conditions
Interventions
MEP-positive + cTBS group:Conventional rehabilitation therapy + continuous cerebellar theta burst stimulation (cTBS)
MEP-negative + cTBS group:Conventional rehabilitation therapy + continuous cerebellar theta burst stimulation (cTBS)
MEP-negative + iTBS group:Conventional rehabilitation therapy + intermittent cerebellar theta burst stimulation (iTBS)
MEP-positive + iTBS group:Conventional rehabilitation therapy + intermittent cerebellar theta burst stimulation (iTBS)
Sponsors
Jinshan Hosptial of Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 80 years old; 2. This is the first occurrence of stroke, or there has been lacunar cerebral infarction in the past but no sequelae remain; 3. Within 3 months of onset, and the condition has been stable in the past week; 4. Clear consciousness, no obvious cognitive impairment, and the Mini-Mental State Examination (MMSE) score is >= 24, able to cooperate with treatment and assessment; 5. Paralysis of one side of the body, the motor function assessment of the affected upper limb and hand is at the Brunnstrom stage II-IV, and the modified Asworth grade is >= 1; 6. Understand the test content and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Wearing a pacemaker, having intracranial or other metallic implants in the body, or having a skull defect; 2.History of epilepsy, women who are lactating or possibly pregnant; 3.Accompanied by severe systemic diseases, such as congestive heart failure, or uncontrolled hypertension or diabetes; 4.Those with pre-existing upper limb diseases affecting treatment, such as upper limb infection, joint surgery, fracture, contracture, amputation, etc; 5.Those with severe visual, hearing, or speech impairments (e.g., deaf-mute individuals), or psychiatric disorders; 6.Recent use of medications that alter cortical excitability (e.g., sedatives, antidepressants).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Tardieu Scale (R1 angle); | — |
Secondary
| Measure | Time frame |
|---|---|
| Motor evoked potential (MEP elicitation status, amplitude, CMCT);Modified Barthel Index;Fugl-Meyer Upper Extremity score; | — |
Countries
China
Contacts
Public ContactTao Feng
Jinshan Hosptial of Fudan University
Outcome results
None listed