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Effective Dose of Oliceridine Combined with Remimazolam for Painless Hysteroscopy: A Prospective Study Using the k-in-a-Row Sequential Design

Effective Dose of Oliceridine Combined with Remimazolam for Painless Hysteroscopy: A Prospective Study Using the k-in-a-Row Sequential Design

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600127385
Enrollment
Unknown
Registered
2026-06-30
Start date
2026-07-01
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometrial polyp

Interventions

Experimental Group:The initial dose is 1.5 mg of oliceridine, followed by 0.3 mg/kg of remimazolam after 1 minute. Adjustments to the oliceridine dose depend on previous procedures. If hysteroscopy fa

Sponsors

Taizhou Hospital of Zhejiang Province
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged over 18 years; 2. Body mass index (BMI) of 18-25 kg/m^2; 3. American Society of Anesthesiologists (ASA) physical status classification of I-II.

Exclusion criteria

Exclusion criteria: 1. Patients who refused to participate in the trial; 2. Patients with hypertension or other abnormalities of cardiac, pulmonary, hepatic, or renal function; 3. Patients with obstructive sleep apnea syndrome or a known difficult airway; 4. Patients with a respiratory tract infection within the past two weeks; 5. Patients with psychiatric disorders or a history of long-term use of sedative or analgesic medications; 6. Patients with a history of allergy to general anesthetic agents.

Design outcomes

Primary

MeasureTime frame
ED50;ED95;

Secondary

MeasureTime frame
adverse event;

Countries

China

Contacts

Public ContactJin Bingxin

Taizhou Hospital of Zhejiang Province

773863775@qq.com+86 576 8512 0120

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026