Acute pancreatitis
Conditions
Interventions
Indomethacin group:Indomethacin suppository 50mg q12h rectal administration, continuous for 7 days
or in mild cases less than 7 days but clinical improvement reached discharge criteria (complete relief of abdominal pain, sustained normal body temperature, C-reactive protein decreased to within 150m
Placebo group:Placebo 50mg q12h rectal administration, continuous for 7 days
Sponsors
Chinese Academy of Medical Science & Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for acute pancreatitis (typical abdominal pain, pancreatic enzyme elevation more than three times the upper limit of normal, typical imaging changes); 2. Time from onset to hospital visit should be within 24 hours, and time from visit to enrollment should be within 8 hours; 3. Age 18-80 years; 4. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Abdominal pain symptoms have persisted for more than 24 hours at the time of consultation; 2. Severe hepatic dysfunction (referring to acute liver failure or decompensated cirrhosis) or abnormal renal function (>1.5 times the normal value); 3. Patients with active gastrointestinal bleeding, peptic ulcers, or other contraindications to NSAIDs; 4. Pregnancy or lactation; 5. Severe cardiovascular or cerebrovascular diseases such as heart failure, myocardial infarction, or stroke; 6. Uncontrolled hypertension; 7. Allergy to NSAID medications; 8. Mental disorders preventing cooperation; 9. Acute pancreatitis caused by malignant tumors; 10. Post-ERCP pancreatitis; 11. Failure to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of organ failure within one week after admission; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality within the first month of hospitalization;Length of stay in the intensive care unit during the first month after admission;Incidence of pancreatic necrosis;Medical economic cost; | — |
Countries
China
Contacts
Public ContactWu Dong
Peking Union Medical College Hospital
Outcome results
None listed