Perioperative Neurocognitive Disorders (PND)
Conditions
Interventions
Healthy volunteer group:None
Sponsors
Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Study Group: (1) Aged 18 to 60 years; (2) American Society of Anesthesiologists (ASA) physical status I-III; (3) Scheduled for elective non-ophthalmologic and non-neurosurgical procedures under general anesthesia; (4) Uncorrected or corrected visual acuity of >= 0.8 in both eyes, with a logarithmic visual acuity difference of = 0.8 in both eyes, with a logarithmic visual acuity difference of <= 0.1 between the two eyes; (4) No history of alcohol or psychoactive substance dependence; (5) Willing to participate in this study and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Study Group: (1) History of visual system disorders: Amblyopia, strabismus, color blindness, or severe ocular dominance; (2) Neuropsychiatric history: Previous history of traumatic brain injury (TBI), stroke, brain tumor, epilepsy, schizophrenia, bipolar disorder, major depressive disorder (MDD), or autism spectrum disorder (ASD); (3) Pharmacological interference: Use of medications modulating the GABAergic or glutamatergic systems within 2 weeks prior to surgery; (4) Special physiological conditions: Pregnant or lactating women; (5) Inability to cooperate: Presence of severe cognitive or motor impairments precluding the completion of the binocular rivalry dynamics test. 2. Control Group (Healthy Volunteers): (1) History of visual system disorders: Amblyopia, strabismus, color blindness, or severe ocular dominance; (2) Neuropsychiatric history: Previous history of traumatic brain injury (TBI), stroke, brain tumor, epilepsy, schizophrenia, bipolar disorder, major depressive disorder (MDD), or autism spectrum disorder (ASD); (3) Pharmacological interference: Use of medications modulating the GABAergic or glutamatergic systems within 2 weeks prior to the baseline test; (4) Special physiological conditions: Pregnant or lactating women; (5) Inability to cooperate: Presence of severe cognitive or motor impairments precluding the completion of the binocular rivalry dynamics test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of Suppression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perceptual switch rate and other rival dynamics parameters;Perioperative clinical assessment scales (including RASS, KSS, CAM, QoR-15, and VAS pain scores); | — |
Countries
China
Contacts
Public ContactGu Xiaoping
Drum Tower Hospital
Outcome results
None listed