Obesity
Conditions
Interventions
Control group. :The control group carried out exercise intervention according to the exercise prescription provided by the "Enjoy Health" APP every week.
Intervention group: all subjects were in the t
Halved staple food combined with information support exercise intervention:Group A: all subjects received half of the staple food for three meals combined with information support exercise interventio
Time-restricted eating combined with information-supported exercise intervention group.:Time-restricted diet combined with information-based support for exercise intervention group: All subjects were
Sponsors
School of Public Health, Peking University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-50 years old, both sexes; 2.BMI>=28kg/m^2; 3. Willing to cooperate with the study and sign the informed consent; 4. Permanent residents nearby; 5. Time-unlimited eating or other types of fasting habits, such as alternate-day fasting, simulated fasting diet; 6. Patients with abnormal glucose metabolism or diabetes (fasting blood glucose > 5.6mmol/L, glycosylated hemoglobin > 5.7%)
Exclusion criteria
Exclusion criteria: 1. Secondary obesity (e.g., hypothyroidism, Cushing syndrome); Use of weight-loss medications within 90 days before screening; 2. Or a weight change of more than 5 kg within 90 days before screening; 3. Pregnant, breastfeeding or planning to become pregnant; 4. Severe heart, liver and kidney dysfunction; 5. Severe mental illness or cognitive impairment, unable to cooperate with the study; 6. Presence of contraindications to exercise (e.g., severe osteoarthritis); 7. Unable or unwilling to follow the prescribed diet and exercise regimen; 8. Long-term use of medications that may significantly affect body weight; 9. Patients with active cancer in any organ system; 10. The researcher believes that the subject has any other factors that may affect the efficacy or safety assessment of this study and is not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body weight;Blood glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body composition;Adipokine;Blood pressure;Heart rate;Fasting blood lipids;Appetite-related hormones;Sugar in urine;Urinary ketone bodies;Fecal omics;Dynamic changes of blood glucose;Fasting glucose;Fasting insulin;A 3-day 24-hour dietary review;Sleep Quality Questionnaire;The CNAQ Appetite questionnaire;Psychological questionnaire;Glycosylated hemoglobin; | — |
Countries
China
Contacts
Public ContactXu Yaxi, Jiang Lanping
School of Public Health, Peking University
Outcome results
None listed