General liver injury, fatty liver, immune-mediated liver injury, inherited metabolic liver diseases, drug-induced hepatitis, etc.
Conditions
Interventions
Retrospective study cohort (Retrospective cohort 1):None
Prospective study cohort (Prospective cohort 2):None
Sponsors
The first affiliated hospital of anhui medical university
Eligibility
Sex/Gender
All
Age
No minimum to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with unexplained liver injury or severe hepatitis(Including general liver injury, fatty liver, immune-mediated liver injury, inherited metabolic liver diseases, drug-induced hepatitis, etc.); 2.Unknown cause liver injury: patients whose liver biochemical abnormalities have not been clinically diagnosed through medical history, serological, immunological tests, etc; 3.Diagnosis of severe hepatitis must comply with the Diagnosis and Treatment Guidelines for Liver Failure (2024 edition); 4.The patient has complete general information, tests/examinations, and blood/body fluid/tissue specimens during hospitalization; 5.Age<80 years old;
Exclusion criteria
Exclusion criteria: 1.Patients with liver injury with clear causes such as hepatitis B virus, autoimmune liver disease, alcoholic liver disease, and liver space occupying lesions; 2.Patients with metastatic liver cancer; 3.There are contraindications for liver puncture: obvious bleeding tendency or severe thrombocytopenia, coagulation dysfunction; Those who are unconscious or unable to cooperate; There is an infected lesion in the puncture path;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete Blood Count;Liver Function Tests;Renal Function Tests;Ammonia Level;Hemostasis and Coagulation Profile;Tumor Markers;Immunoglobulins;Antinuclear Antibodies; | — |
Countries
China
Contacts
Public ContactLi Wenting
The first affiliated hospital of anhui medical university
Outcome results
None listed