Childhood Community-Acquired Pneumonia
Conditions
Interventions
Childhood Community-Acquired Pneumonia Group:None
Sponsors
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1.Children aged from 29 days to 18 years old, both genders are eligibl; 2.?Baseline sample collection shall be completed within 48 hours after admission for patients meeting the pneumonia diagnostic criteria; 3.Voluntarily sign the informed consent form before the trial, and agree to participate in all scheduled visits, examinations and treatments in accordance with the requirements of the study protocol;
Exclusion criteria
Exclusion criteria: 1.Children with severe missing clinical data or whose outcomes cannot be traced; 2.Children with pneumonia secondary to severe infection at other sites (such as purulent meningitis, osteomyelitis, etc.); 3.Children with hospital-acquired pneumonia (HAP); 4.Underlying severe immune dysfunction: including tuberculosis infection, HIV positivity, primary immunodeficiency disease, patients with malignant tumor undergoing chemotherapy, and post-transplant patients; 5.Children with pneumonia characterized by persistent unhealed infection (disease course > 4 weeks) or repeated recurrence (recurrence > 2 times within 1 year); 6.Severe allergy history (e.g., previous anaphylaxis)?; 7.Exclusion for drug interference: Children who received systemic glucocorticoid therapy (intravenous infusion or oral administration) within 14 days before admission. **Note: Children who only received nebulized inhalation or local glucocorticoid therapy before admission can be included, but the drug name, dosage and frequency of use must be recorded in detail in the Case Report Form (CRF), and will be used as a adjusted covariate for subsequent analysis. 8.Children who have used immunosuppressants (such as cyclophosphamide, cyclosporine, etc.) or biological agents within 14 days before admission;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Day-28 mortality;Whether the condition progresses to severe pneumonia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Days of mechanical ventilation in mechanically ventilated patients;Changes in oxygenation index in children with severe illness;Duration of fever (calculated in hours or days);Total length of hospital stay and length of ICU stay;90-day all-cause mortality; | — |
Countries
China
Contacts
Public ContactYingxia Zheng
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed