Significant bradycardia includes the following conditions: cardiac inhibitory vasovagal syncope
Conditions
Interventions
Sham Surgery Group:Sham Surgery
Surgical Group:Cardiac Ganglion Ablation
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18 - 65 years old; 2. Have symptoms related to bradycardia (syncope, dizziness, blackout, palpitations, fatigue, listlessness, inability to concentrate and decreased activity endurance, etc.); 3. Meet one of the following conditions: (1) Dynamic electrocardiogram shows an average heart rate of less than 50 beats per minute or there is a heart arrest lasting more than 3 seconds during the day; (2) Transient second or third degree atrioventricular conduction block without hemodynamic disorders during the day; 4. The atropine test showed that the sinus heart rate increased by = 25%, or the heart rate was = 90 beats per minute, or the atrioventricular conduction block was significantly improved to be no more than first-degree atrioventricular conduction block.
Exclusion criteria
Exclusion criteria: 1. A history of severe trauma caused by bradycardia; 2. Regular use of antiarrhythmic drugs within the past 3 months; 3. Prior implantation of a cardiac pacemaker; 4. Existing implantation of, or indication for implantation of, electronic devices with pacing function, such as cardiac contractility modulators (CCMs), implantable cardioverter-defibrillators (ICDs), or cardiac resynchronization therapy (CRT) devices; 5. Bradycardia or atrioventricular block caused by medications or other reversible factors (e.g., hyperkalemia, hypothyroidism); 6. Bradycardia or atrioventricular block associated with obstructive sleep apnea syndrome (OSAS); 7. Coronary revascularization within the past 3 months, or unstable coronary heart disease despite standardized medical treatment or revascularization; 8. Stroke or transient ischemic attack (TIA) within the past 3 months; 9. A history of open-heart surgery; 10. Severe congenital heart disease; 11. Complicated with severe ventricular arrhythmia; 12. Severe cardiac insufficiency with left ventricular ejection fraction (LVEF) <= 35%; 13. Severe cardiomyopathy, such as hypertrophic obstructive cardiomyopathy (HOCM), dilated cardiomyopathy (DCM), or cardiac amyloidosis; 14. Severe aortic or mitral valve stenosis; 15. Pregnancy or lactation period; 16. Expected survival time of less than 1 year; 17. Refusal to sign the informed consent form; 18.Other conditions deemed ineligible by the researchers;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Average Heart Rate?RR Interval and PR Interval by Holter.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart Rate Variability;Quality of Life Score; | — |
Countries
China
Contacts
Public ContactNing Zhou
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed