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Individualized PRF Modifications for Gingival Papilla Regeneration: Clinical Outcomes and Homeostatic Mechanisms

Individualized PRF Modifications for Gingival Papilla Regeneration: Clinical Outcomes and Homeostatic Mechanisms

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600127313
Enrollment
Unknown
Registered
2026-06-29
Start date
2026-01-15
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival papilla recession

Interventions

Treatment Group:Reconstruction of gingival papillae recession by PRF Injection

Sponsors

Shanghai Stomatological Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. Age: 18-64 years; 2. According to Nordland classification, there is type I or II gingival papillary retraction between adjacent natural teeth (Figure 1); 3. Plaque index of the injected tooth is less than 20%, no Bleeding on Probing (BOP), Probing depth (PD) <= 4 mm; 4. Good oral hygiene habits and medical compliance; 5. Able to obtain informed consent.

Exclusion criteria

Exclusion criteria: 1. Smokers; 2. Pregnant or lactating women; 3. Those who have taken drugs with the side effect of gingival hyperplasia (such as phenytoin sodium, cyclosporine, nifedipine, etc.); 4. Loose teeth; 5. The width of the attached gingiva is less than 1 mm; 6. People with oral mucosal diseases; 7. Patients undergoing orthodontic treatment; 8. Abnormal coagulation function and blood routine indicators; 9. Those who have undergone periodontal surgery at the treatment site in the past 12 months; 10. Those with infectious diseases such as hepatitis B and AIDS, as well as those deemed unsuitable for this clinical trial by the researchers for other reasons.

Design outcomes

Primary

MeasureTime frame
Papillary Infundibulum Score (PIS);Black Triangle Area;

Secondary

MeasureTime frame
Patient Aesthetic Satisfaction;Patient Pain Score;

Countries

China

Contacts

Public ContactZhang Yiding

Shanghai Stomatological Hospital, Fudan University

yidingz1593@163.com+86 21 54668023

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026