Breast cancer surgery
Conditions
Interventions
Dex group (dexmedetomidine combined with propofol group):Propofol 4-6 mg/kg/h + dexmedetomidine 0.5 µg/kg/h (initial dose 1 µg/kg, infusion over more than 10 minutes), stop medication 30 minutes befor
Remi group (remifentanil combined with propofol group):Propofol 4-6 mg/kg/h + remifentanil 0.2 µg/kg/min, stop medication 5 minutes before the end of surgery
Sponsors
The First Affiliated Hospital of the Baotou Medical College of Inner Mongolia University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age range: 18 - 75 years old; 2.ASA classification levels I-III; 3.Planning to undergo breast cancer surgery; 4.Sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Severe dysfunction of the heart, lungs, liver and kidneys (eGFR < 30 ml/min); 2. Bradycardia (less than 50 beats per minute) or atrioventricular conduction block; 3. Long-term use of sedative, analgesic and antidepressant drugs; 4. Obese (with a BMI of 35 kg/m^2 or above); 5. History of drug or alcohol abuse; 6. Mental illness or communication disorder; 7. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score at 24 hours and 48 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to emergence, extubation time, and duration of stay in the postanesthesia care unit;Resting and movement NRS scores;Rescue analgesia requirement;Cortisol and interleukin-6 levels;Heart rate, blood pressure, and bispectral index (BIS); | — |
Countries
China
Contacts
Public ContactCai Qiang
The First Affiliated Hospital of the Baotou Medical College of Inner Mongolia University of Science and Technology
Outcome results
None listed