Coronary artery disease
Conditions
Interventions
Angiography-Guided PCI:Standard Angiography-Guided PCI
Virtual Stenting-Guided PCI Optimization:Virtual Stenting-Guided PCI Optimization
Sponsors
Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with coronary heart disease who are 18 years or older and are undergoing coronary angiography; 2. There is at least one lesion in a major coronary artery with an estimated reference vessel diameter of 2.5 mm or more, showing 70-95% narrowing based on visual assessment; 3. Pre-procedure calculated QFR of the target vessel is less than 0.8, and the lesion is technically feasible for percutaneous coronary intervention (PCI) based on angiographic evaluation; 4. Able to understand the trial design and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Clinical or angiographic features that can cause QFR calculation failure: (1) Left main coronary artery disease; (2) Lesions at the origin of the left branch or right coronary artery; (3) Previous coronary artery bypass graft surgery; (4) Persistent ventricular arrhythmia; (5) Chronic total occlusion lesions; (6) Target vessel stenosis over 95% with TIMI flow less than grade III; (7) Severe calcified lesions; (8) In-stent restenosis lesions. 2. PCI to the target artery provides Rentrop grade 2 or 3 collateral blood flow to another vessel; 3. Patients planned for drug-coated balloon treatment of coronary in-situ lesions; 4. Expected lifespan less than 1 year due to non-cardiac causes; 5. Cardiogenic shock or refractory hypotension (Killip class IV); 6. Use of intravenous vasoactive drugs, intra-aortic balloon pump, or other mechanical circulatory support devices; 7. Patients receiving endotracheal intubation; 8. After successful intravenous thrombolysis, patients who do not undergo angiography and necessary intervention within 24 hours; 9. Creatinine clearance < 30 ml/kg calculated by the Cockcroft-Gault formula; 10. Pregnant women; 11. Patients allergic to iodine-containing contrast agents; 12. Patients who are expected not to tolerate at least 6 months of antiplatelet therapy; 13. Patients planning any surgery within 6 months; 14. Other situations that may interfere with follow-up (such as dementia, substance abuse, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major Adverse Cardiovascular Events (MACE); | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-PCI Physiological Optimization Achievement Rate; | — |
Countries
China
Contacts
Public ContactYing Song
Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed