Alzheimers disease
Conditions
Interventions
Rule-based Cognitive Training Group:Rule-based Cognitive Training
Al-based Cognitive Training Group:Al-based Cognitive Training
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Inpatients or outpatients aged 50–90 years; 2.Patients diagnosed with amnestic mild cognitive impairment (aMCI) due to AD or mild dementia due to AD, based on the 2018 NIA-AA clinical diagnostic criteria established by the National Institute on Aging and the Alzheimer’s Association; 3.Neuropsychological assessment showing MMSE scores between 18 and 26, and a CDR score of 0.5 or 1; 4.Able to communicate fluently in Chinese (non-illiterate); 5.For those currently receiving cholinesterase inhibitor therapy (e.g., donepezil or rivastigmine), the treatment dose must be stable, defined as a fixed dosage administered continuously for at least six weeks, with no adjustment of the medication regimen during the study period; 6.Provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1.Documented history of cerebrovascular stroke, with clear neurological deficits at onset and corresponding responsible lesions on neuroimaging; 2.Moderate to severe white matter lesions (Fazekas score 3–6); 3.Presence of any cause of consciousness disorder; 4.Severe aphasia or motor disability that prevents completion of neuropsychological assessments; 5.Current psychiatric disorders; 6.History of alcohol dependence, drug addiction, traumatic brain injury, epilepsy, encephalitis, normal-pressure hydrocephalus, or other neurological disorders that may cause cognitive impairment; 7.Systemic diseases that may contribute to mild cognitive impairment (e.g., hepatic or renal insufficiency, endocrine disorders, vitamin deficiencies); 8.Considered unsuitable for participation by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination (MMSE) score;Activities of Daily Living (ADL) score;Clinical Dementia Rating (CDR) score; | — |
Countries
China
Contacts
Public ContactYu Yueyi
Xuanwu Hospital Capital Medical University
Outcome results
None listed