Periorbital wrinkles and laxity
Conditions
Interventions
treatment side vs. control side:The left and right periorbital areas of each participant were randomly assigned, with one side designated as the treatment side that received bipolar radiofrequency tre
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
Female
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female subjects aged 35–65 years; 2. Mild to moderate periorbital skin laxity or fine lines bilaterally, with or without mild to moderate lower eyelid tissue protrusion (skin laxity type or mild fat protrusion type bags under eyes); 3. Generally symmetrical periorbital wrinkles and skin laxity between left and right eyes, with at least one periorbital site (lateral canthal area, infraorbital area, or medial canthal area) scoring Grade I–II on the Fitzpatrick Wrinkle and Elastosis Scale (FWES); 4. Intact skin without significant scarring, active inflammation, infection, or other dermatological conditions that may affect energy-based treatment; 5. Subjects voluntarily participating in the study, having signed the informed consent form, and capable of completing all treatments and follow-up visits as scheduled.
Exclusion criteria
Exclusion criteria: 1. History of periorbital radiofrequency, ultrasound, laser, injectable filler, or surgical treatments within 6 months prior to enrollment; 2. Presence of significant orbital septal fat herniation (moderate to severe bags under eyes), or marked lower eyelid edema, lymphatic drainage impairment type bags under eyes; 3. Concomitant severe ocular diseases (such as dry eye syndrome, meibomian gland dysfunction, glaucoma, history of ocular surgery) or recent periorbital cosmetic procedures; 4. Pregnancy, lactation, or planned pregnancy; 5. Use of photosensitizing agents or medications affecting wound healing; 6. Concomitant systemic diseases (such as uncontrolled diabetes mellitus, immune dysfunction, keloid predisposition, metallic implants, or cardiac pacemaker carriers).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fitzpatrick Wrinkle and Elastosis Scale Evaluation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Facial Laxity Rating Scale;Global Aesthetic Improvement;Antera3D measurement;VISIA imaging;Transepidermal water loss; | — |
Countries
China
Contacts
Public ContactFenglin Zhuo
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed