Acute Ischemic Stroke
Conditions
Interventions
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. No gender restriction; 3. Definite diagnosis of acute ischemic stroke, with imaging confirmation of intracranial anterior circulation large vessel occlusion (intracranial segment of the internal carotid artery or M1 segment of the middle cerebral artery) as the culprit vessel; 4. Time from symptom onset to hospital arrival = 6. 6. Preoperative Alberta Stroke Program Early CT Score (ASPECTS) > 5. 7. The subject or their legally authorized representative agrees to participate in the study and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Preoperative MRA or CTA confirms moderate-to-severe atherosclerotic stenosis (stenosis rate >= 50%) in the ipsilateral/contralateral carotid artery or proximal intracranial culprit artery. 2. Preoperative imaging (NCCT or MRI) indicates any type of intracranial hemorrhage on the ipsilateral side, including but not limited to parenchymal hemorrhage, subarachnoid hemorrhage (SAH), or subdural/epidural hematoma. 3. History of severe intracerebral hemorrhage, epilepsy, or active brain tumor. 4. Extensive skull defect, deformity, or severe injury to the scalp skin that prevents sensor placement. 5. History of prior cerebral infarction in the contralateral hemisphere. 6. Use of medications or treatments that may affect cerebral perfusion and cerebral oxygen saturation. 7. Presence of severe anemia upon admission, defined as hemoglobin (Hb) < 90 g/L (or < 9 g/dL). 8. Severe pulmonary disease, severe cardiac dysfunction, hepatic or renal insufficiency, severe infection, advanced malignancy, or other conditions with a life expectancy < 3 months. 9. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of persistent tissue hypoperfusion on the lesion side at 24 hours after mechanical thrombectomy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Infarct core volume;Incidence of intracranial hemorrhagic transformation at discharge;Incidence of symptomatic intracranial hemorrhage (SICH) at discharge;Hypoperfusion intensity ratio;Cerebral blood flow asymmetry;Overall mortality;Malignant cerebral edema during hospitalization.;Futile recanalization;Target Optimal Reperfusion;Hypoperfused area on the lesion side;Early neurological deterioration rate;Early neurological improvement rate;Adverse events;Distribution analysis of 90-day post-procedure mRS scores.;Volume of hypoperfusion;Proportion of patients with 90-day post-procedure mRS score of 0–2;Severe postoperative cerebral hypoxic event;Change in NIHSS score from baseline to discharge.; | — |
Countries
China
Contacts
Public ContactJi Xunming
Xuanwu Hospital Capital Medical University
Outcome results
None listed