Anxiety disorder with depression
Conditions
Interventions
experimental group:Oxazepam combined with escitalopram oxalate
Oxazepam, 15–30 mg, PO, q.d.–t.i.d.
Escitalopram Oxalate, 10-20mg, PO, q.d.–t.i.d.
Control group:Tandospirone combined with Escitalopram
Tandospirone, 10-20m, PO, t.i.d.
Escitalopram, 10-20m, PO, q.d.
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18~65 years (including the boundaries), no restriction on gender; 2.Meet the diagnostic criteria for DSM-5 anxiety disorders (including various subtypes such as generalized anxiety disorder, panic disorder, and unspecified anxiety disorder), with a Hamilton Anxiety Scale score >= 14. 3.Has core complaints of depressive symptoms, with a Hamilton-24 Depression Rating Scale score >= 7 points; 4.Voluntarily join the project and sign the informed consent form, and be able to complete the study in accordance with the requirements of the trial protocol;
Exclusion criteria
Exclusion criteria: 1.Patients with major depressive disorder (HAMD-24 >= 24), and those with severe suicidal tendencies (item 3 of HAMD "suicide" >= 3 points); 2.Patients diagnosed with schizophrenia, schizoaffective disorder, delusional disorder, substance dependence, or substance-induced mental disorders, and patients with psychotic symptoms; 3.A history of neurological diseases or major physical illnesses (such as thyroid diseases, systemic lupus erythematosus, lung, liver and kidney damage, infections, major trauma, etc.); 4.Those allergic to oxazepam or escitalopram; 5.Pregnant women, breastfeeding women, or those who plan to have children in the near future; 6.Participants deemed unsuitable for clinical trials by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in HAMA total score;HAMA response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in PSQI score;TESS score; | — |
Countries
China
Contacts
Public ContactYu Haihang
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed