Recurrent Oral Ulcer(ROU), also known as Recurrent Aphthous Ulcer (RAU)
Conditions
Interventions
Experimental Group:Receive oral hydroxychloroquine
Control group:Receive oral prednisone treatment
Sponsors
West China Hospital of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years; 2.With a history of oral ulcers lasting more than 6 months and an ulcer recurrence interval of no more than 2 days; 3.No improvement in ulcer recurrence interval after previous topical medication treatment; 4.No obvious improvement in recurrence interval following prior oral glucocorticoid therapy; 5.Normal blood pressure, pulse, respiration, body temperature and electrocardiogram. 6.All participants voluntarily enroll in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Those with hypersensitivity to hydroxychloroquine or glucocorticoids; 2.Patients with abnormal ophthalmological examination, routine blood test, liver or renal function results; 3.Pregnant women, lactating women and subjects with current pregnancy plans; 4.Patients complicated with severe systemic diseases, including a history of ocular fundus disorders, diabetes mellitus, hematological diseases, cardiovascular diseases, hepatic disorders, renal insufficiency, rheumatic diseases and other related conditions; 5.Subjects receiving systematic therapy within 3 months or topical treatment within 2 weeks; 6.Patients unable to complete study follow-up (e.g., hospitalization, mental disorders, poor treatment compliance);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence interval of ulcer; | — |
Secondary
| Measure | Time frame |
|---|---|
| Days of ulcer healing;The number of ulcers;Numeric rating scale; | — |
Countries
China
Contacts
Public ContactHongmei Zhou
West China Hospital of Stomatology, Sichuan University
Outcome results
None listed