Postoperative Gastrointestinal Dysfunction
Conditions
Interventions
Oliceridine analgesic pump group:Patient-controlled intravenous analgesia (PCIA): Oliceridine 0.4 mg/kg plus tropisetron 6 mg diluted with normal saline to a final volume of 100 mL. A
Sufentanil analgesic pump group:Patient-controlled intravenous analgesia (PCIA): Sufentanil 2 µg/kg and tropisetron 6 mg are diluted with normal saline to a total volume of 100 mL. A
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for laparoscopic colorectal cancer surgery under general anesthesia; 2. Age 45 years and above, but not exceeding 80 years; 3. ASA classification: grades I - III; 4. BMI 18-30 kg/m^2; 5. Patients who received patient-controlled intravenous analgesia after the operation.
Exclusion criteria
Exclusion criteria: 1. Allergy to drugs used during anesthesia and postoperative analgesia; 2. History of chronic pain or long-term use of opioid drugs; 3. Long-term use of psychotropic drugs or history of drug abuse; 4. Complicated with severe respiratory diseases, severe cardiovascular and cerebrovascular diseases, or severe liver and kidney dysfunction; 5. Had a surgical history in the last 3 months, and previously undergone colorectal surgery; 6. Suspected intestinal obstruction; 7. Has participated in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first postoperative flatus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first postoperative defecation;Postoperative pain numerical rating scale (NRS) scores;Postoperative Gastrointestinal Function Score (I-FEED);Quality of postoperative recovery;Incidence of postoperative adverse reactions;Time to first ambulation;Number of patient-controlled analgesia pump bolus requests within 24 hours postoperatively;Time to first oral feeding; | — |
Countries
China
Contacts
Public ContactXiuxia Chen
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed