Hereditary bleeding disorders
Conditions
Interventions
Case group:None
Sponsors
The First People's Hospital of Foshan
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients hospitalized and treated at Foshan First People’s Hospital in 2024; 2.Recurrent unexplained bleeding after surgery or trauma; 3.Normal routine coagulation tests (PT, APTT, FIB, TT), platelet count and platelet aggregation function; 4.Markedly elevated plasma TM level (>100 TU/ml); 5.Confirmed heterozygous THBD c.1611C>A mutation via genetic testing;
Exclusion criteria
Exclusion criteria: 1.Coexistence of other confirmed hereditary hemorrhagic disorders (e.g., hemophilia, von Willebrand disease); 2.Comorbidities causing secondary elevation of TM (e.g., DIC, severe hepatic or renal insufficiency, active malignant tumors); 3.Receiving anticoagulant or antiplatelet therapy at enrollment; 4.Incomplete clinical data insufficient for standardized case report preparation;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma Thrombomodulin Level; | — |
Countries
China
Contacts
Public ContactHe Jianlun
The First People's Hospital of Foshan
Outcome results
None listed