Acute-on-chronic liver failure with all etiologies
Conditions
Interventions
Sponsors
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Acute liver injury (ACLF) occurring on the basis of various chronic hepatitis, with the first test results at our hospital meeting the COSSH-ACLF diagnostic criteria: TB = 12mg/dL and INR = 1.5.
Exclusion criteria
Exclusion criteria: Any one of the following criteria requires exclusion: 1. Age 80 years; 2. Pregnancy; 3. Malignant tumors; 4. Severe chronic underlying diseases, such as chronic kidney insufficiency (uremia stage), chronic heart failure (grade III-IV), coronary heart disease patients taking anticoagulants after interventional surgery, severe sequelae from cerebral hemorrhage or infarction (such as lower limb paralysis or hemiplegia), myelofibrosis and aplastic anemia, acute exacerbation of chronic obstructive pulmonary disease, systemic complications arising from high blood pressure, thyroid diseases, etc.; 5. Received hormone and/or immunosuppressive treatment in the past month for non-liver diseases, such as using hormones for autoimmune diseases, anti-rejection drugs for organ transplants, etc.; 6. Severe mental illnesses, such as schizophrenia, depression, mania, etc.; 7. Contraindications for hormone therapy, such as gastrointestinal ulcers, severe infections, severe osteoporosis, uncontrolled hypertension, diabetes, etc.; 8. Others, such as HIV, syphilis, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28/90 days survival status; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function and other biochemical indicators; | — |
Countries
China
Contacts
Public ContactJun Li
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed